منابع مشابه
Differential Localization of G Protein βγ Subunits
G protein βγ subunits play essential roles in regulating cellular signaling cascades, yet little is known about their distribution in tissues or their subcellular localization. While previous studies have suggested specific isoforms may exhibit a wide range of distributions throughout the central nervous system, a thorough investigation of the expression patterns of both Gβ and Gγ isoforms with...
متن کاملMorphine-induced place preference affects mRNA expression of G protein α subunits in rat brain.
BACKGROUND The conditioned place preference (CPP) test is an animal model serving to assess addictive potential of drugs in which environmental cues become associated with the subjective effects of drugs of abuse. Morphine, a known addictive drug, is an agonist of opioid receptors that couple to the G(i/o) family of guanine nucleotide-binding proteins (GP). We have recently found that chronic t...
متن کاملMolecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits.
We have shown that resistance to inhibitors of cholinesterase 8 (Ric-8) proteins regulate an early step of heterotrimeric G protein α (Gα) subunit biosynthesis. Here, mammalian and plant cell-free translation systems were used to study Ric-8A action during Gα subunit translation and protein folding. Gα translation rates and overall produced protein amounts were equivalent in mock and Ric-8A-imm...
متن کاملActivated G protein α s subunits increase the ethanol sensitivity of human glycine receptors.
It is well known that ethanol modulates the function of the Cys loop ligand-gated ion channels, which include the inhibitory glycine receptors (GlyRs). Previous studies have consistently shown that transmembrane and extracellular sites are essential for ethanol actions in GlyRs. In addition, recent evidence has shown that the ethanol modulation of GlyRs is also affected by G protein activation ...
متن کاملGAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
terized G protein GAP is phospholipase C-b, which is Summary both a GAP for Gqa and the effector that is activated by that G protein (Berstein et al., 1992; Biddlecome et al., A novel class of regulators of G protein signaling (RGS) 1996). The GTPase activity of the a subunit of transducin proteins has been identified recently. Genetic eviis also stimulated by its effector, the g subunit of a r...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.38.23594